Cat. No. 5098
Chemical Name: 1,1'-[(5-Chloro-2,4-pyrimidinediyl)b
Biological ActivityPotent Ack1 and anaplastic lymphoma kinase (ALK) dual inhibitor (IC50 values are 4 and 12 nM respectively). Inhibits lung cancer H3122 cell proliferation (IC50 = 80 nM). Attenuates H3122 cell xenograft tumor growth in mice. Orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Lee et al (2014) ALK inhibitors of bis-ortho-alkoxy-para-piperazinesubstituted-pyrimidines and -triazines for cancer treatment. Arch.Pharm.Res. 37 1130. PMID: 24446111.
Park et al (2013) Novel bis-ortho-alkoxy-para-piperazinesubstituted-2,4-dianilinopyrimidines (KRCA-0008) as potent and selective ALK inhibitors for anticancer treatment. Bioorg.Med.Chem.Lett. 23 6192. PMID: 24095090.
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Keywords: KRCA 0008, supplier, KRCA0008, Potent, anaplastic, lymphoma, kinase, ALK, Ack1, inhibitors, inhibits, antitumor, tyrosine, kinases, orally, bioavailable, TNK2, Tocris Bioscience, ALK Inhibitor products