AdipoRon hydrochloride

Cat. No. 5096

AdipoRon hydrochloride C27H28N2O3.HCl [1781835-20-8]

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Chemical Name: 2-(4-Benzyoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide hydrochloride

Biological Activity

Agonist of adiponectin receptors AdipoR1 and AdipoR2 (Kd values are 1.8 and 3.1 μM respectively). Activates AMPK and PPARα signaling; ameliorates insulin resistance, dyslipidemia and glucose intolerance in db/db mice. Orally active antidiabetic agent.

Technical Data

M.Wt:
464.98
Formula:
C27H28N2O3.HCl
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
1781835-20-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Okada-Iwabu et al (2013) A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature 503 493. PMID: 24172895.

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Keywords: AdipoRon hydrochloride, supplier, antidiabetic, adiponectin, receptors, ApoR1, ApoR2, agonists, orally, active, Tocris Bioscience, Other Peptide Receptor products

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