DBM 1285 dihydrochloride

Cat. No. 5095

DBM 1285 dihydrochloride C21H22FN5S.2HCl

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Chemical Name: N-Cyclopropyl-4-[4-(4-fluorophenyl)-2-(4-piperidinyl)-5-thiazolyl]-2-pyrimidinamine dihydrochloride

Biological Activity

p38 MAPK inhibitor. Supresses p38 phosphorylation and LPS-induced TNF-α production in macrophages and in vivo. Attenuates zymosan-induced inflammation and adjuvant-induced arthritis in murine models. Orally active.

Technical Data

M.Wt:
468.42
Formula:
C21H22FN5S.2HCl
Solubility:
Soluble to 100 mM in water
Purity:
>98 %
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Kang et al (2010) DBM1285 suppresses tumor necrosis factor α production by blocking p38 mitogen-activated protein kinase/mitogen-activated protein kinase-activated protein kinase 2 signaling pathway. J.Pharmacol.Exp.Ther. 334 657. PMID: 20427474.

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Keywords: DBM 1285 dihydrochloride, supplier, DBM1285, dihydrochloride, P38, MAPK, inhibits, inhibitors, TNF-alpha, TNF-a, TNF-α, mitogen, activated, protein, kinase, 917811-28-0, Tocris Bioscience, p38 MAPK Inhibitor products

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