Cat. No. 5089
Chemical Name: N-(9-Cyclopropyl-1-oxononyl)-N-hydr
Biological ActivitySelective histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 μM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). Inhibits growth of HeLa and KYSE-150 cancer cells in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Suzuki et al (2013) Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity. J.Med.Chem. 56 (7222). PMID: 23964788.
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Keywords: TC-E 5002, supplier, TC-E5002, histone, demthylases, KDM2/7, KDM2A, KDM7A, KDM7B, subfamily, inhibitors, inhibits, Tocris Bioscience, Histone Demethylase Inhibitor products
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KDM4A inhibitor; also NF-κB activator
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