TC-E 5002

Cat. No. 5089

TC-E 5002 C15H27NO4 [1453071-47-0]

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Chemical Name: N-(9-Cyclopropyl-1-oxononyl)-N-hydroxy-β-alanine

Biological Activity

Selective histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 μM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). Inhibits growth of HeLa and KYSE-150 cancer cells in vitro.

Technical Data

M.Wt:
285.38
Formula:
C15H27NO4
Solubility:
Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1453071-47-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Suzuki et al (2013) Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity. J.Med.Chem. 56 (7222). PMID: 23964788.

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Keywords: TC-E 5002, supplier, TC-E5002, histone, demthylases, KDM2/7, KDM2A, KDM7A, KDM7B, subfamily, inhibitors, inhibits, Tocris Bioscience, Histone Demethylase Inhibitor products

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