Cat. No. 5086
Chemical Name: 2-[[3-(Hexyloxy)-5,6,7,8-tetrahydro
Biological ActivityRXR antagonist (pA2 = 7.11). Triggers dissociation of RXR tetramers. Attenuates cell proliferation and induces apoptosis in MCF-7 breast cancer cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Nakayama et al (2011) Discovery of a potent retinoid X receptor antagonist structurally closely related to RXR agonist NEt-3IBIB. J.Med.Chem.Lett 2 896. PMID: 24900278.
Yasmin et al (2010) Inhibition of mammary carcinoma cell growth by RXR is mediated by the receptor's oligomeric switch. J.Mol.Biol. 397 1121. PMID: 20188110.
Takahashi et al (2002) Novel retinoid X receptor antagonists: specific inhibition of retinoid synergism in RXR-RAR heterodimer actions. J.Med.Chem. 45 3327. PMID: 12139443.
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Keywords: PA 452, supplier, PA452, RXR, tetramers, retinoid, X, receptors, antagonists, Tocris Bioscience, Retinoid X Receptor Antagonist products
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