Cat. No. 5086
Chemical Name: 2-[[3-(Hexyloxy)-5,6,7,8-tetrahydro
Biological ActivityRXR antagonist (pA2 = 7.11). Triggers dissociation of RXR tetramers. Attenuates cell proliferation and induces apoptosis in MCF-7 breast cancer cells.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Nakayama et al (2011) Discovery of a potent retinoid X receptor antagonist structurally closely related to RXR agonist NEt-3IBIB. J.Med.Chem.Lett 2 896. PMID: 24900278.
Yasmin et al (2010) Inhibition of mammary carcinoma cell growth by RXR is mediated by the receptor's oligomeric switch. J.Mol.Biol. 397 1121. PMID: 20188110.
Takahashi et al (2002) Novel retinoid X receptor antagonists: specific inhibition of retinoid synergism in RXR-RAR heterodimer actions. J.Med.Chem. 45 3327. PMID: 12139443.
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Keywords: PA 452, supplier, PA452, RXR, tetramers, retinoid, X, receptors, antagonists, Tocris Bioscience, Retinoid X Receptor Antagonist products
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