MN 64

Cat. No. 5084

MN 64 C18H16O2 [92831-11-3]

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Chemical Name: 2-[4-(1-Methylethyl)phenyl]-4H-1-benzopyran-4-one

Biological Activity

Potent and selective tankyrase (TNKS) inhibitor (IC50 values are 6 and 72 nM for TNKS1 and TNKS2 respectively). Has no significant effect on PARP-1 or PARP-2 (IC50 >19 μM). Inhibits WNT/β-catenin signaling-dependent Super-TopFlash (STF) luciferase activity.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Narwal et al (2013) Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J.Med.Chem. 56 7880. PMID: 24116873.

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Keywords: MN 64, supplier, MN64, potent, selective, tankyrase, inhibitors, TNKS, TNKS1, TNKS2, WNT, inhibits, Tocris Bioscience, Tankyrase Inhibitor products

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