Cat. No. 5084
Chemical Name: 2-[4-(1-Methylethyl)phenyl]-4H-1-be
Biological ActivityPotent and selective tankyrase (TNKS) inhibitor (IC50 values are 6 and 72 nM for TNKS1 and TNKS2 respectively). Has no significant effect on PARP-1 or PARP-2 (IC50 >19 μM). Inhibits WNT/β-catenin signaling-dependent Super-TopFlash (STF) luciferase activity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Narwal et al (2013) Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J.Med.Chem. 56 7880. PMID: 24116873.
If you know of a relevant reference for MN 64 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses MN 64 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: MN 64, supplier, MN64, potent, selective, tankyrase, inhibitors, TNKS, TNKS1, TNKS2, WNT, inhibits, Tocris Bioscience, Tankyrase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent PARP inhibitor; orally bioavailableEntecavir
Potent and selective hepatitis B virus inhibitorBRACO 19 trihydrochloride
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.