Cat. No. 5082
Chemical Name: 3-[[(2-Methylphenyl)methyl]thio]-6-
Biological ActivityIncreases expression of glutamate transporter EAAT2 in PA-EAAT2 cells. Displays neuroprotective activity in vivo. Shown to improve learning and memory, restore synaptic integrity and reduce amyloid plaque burden in APPSw/Ind mice.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Lin et al (2013) : Mechanism of LDN-212320 induction of glutamate transporter EAAT2 expression . Society for Neuroscience (Abstract) 99.
Takahashi et al (2013) A small molecule modulator of glutamate transporter EAAT2 ameliorates Alzheimer’s-like pathologies and memory deficits in APPSw/Ind mice. Society for Neuroscience (Abstract) 103.
Lin et al (2012) Glutamate transporter EAAT2: a new target for the treatment of neurodegenerative diseases. Future Med Chem 4 1689. PMID: 22924507.
Xing et al (2011) Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators. Bioorg.Med.Chem.Lett. 21 5774. PMID: 21875806.
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Keywords: LDN 212320, supplier, LDN212320, glutamate, transporters, EAAT2, Excitatory, Amino, Acid, Transporters, Monoamine, Neurotransmitters, Alzheimer's, disease, Tocris Bioscience, Glutamate Transporter products
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