LDN 212320

Cat. No. 5082

LDN 212320 C17H15N3S [894002-50-7]

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Chemical Name: 3-[[(2-Methylphenyl)methyl]thio]-6-(2-pyridinyl)-pyridazine

Biological Activity

Increases expression of glutamate transporter EAAT2 in PA-EAAT2 cells. Displays neuroprotective activity in vivo. Shown to improve learning and memory, restore synaptic integrity and reduce amyloid plaque burden in APPSw/Ind mice.

Technical Data

Soluble to 100 mM in DMSO and to 20 mM in ethanol
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Lin et al (2013) : Mechanism of LDN-212320 induction of glutamate transporter EAAT2 expression . Society for Neuroscience (Abstract) 99.

Takahashi et al (2013) A small molecule modulator of glutamate transporter EAAT2 ameliorates Alzheimer’s-like pathologies and memory deficits in APPSw/Ind mice. Society for Neuroscience (Abstract) 103.

Lin et al (2012) Glutamate transporter EAAT2: a new target for the treatment of neurodegenerative diseases. Future Med Chem 4 1689. PMID: 22924507.

Xing et al (2011) Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators. Bioorg.Med.Chem.Lett. 21 5774. PMID: 21875806.

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Keywords: LDN 212320, supplier, LDN212320, glutamate, transporters, EAAT2, Excitatory, Amino, Acid, Transporters, Monoamine, Neurotransmitters, Alzheimer's, disease, Tocris Bioscience, Glutamate Transporter products

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