ABT 089 dihydrochloride

Cat. No. 5079

ABT 089 dihydrochloride C11H16N2O.2HCl [161416-61-1]

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Chemical Name: 2-Methyl-3-[(2S)-pyrrolidinylmethoxy]pyridine dihydrochloride

Biological Activity

High affinity and selective α4β2 partial agonist (Ki = 16 nM). Exhibits >1000-fold and >10,000-fold selectivity for α4β2 over α1β1γ1 and α7 receptors respectively. Neuroprotective against glutamate-induced toxicity in rat cortical neurons in vitro. Enhances cognitive performance in vivo. Orally bioavailable and brain penetrant.

Technical Data

Soluble to 100 mM in water and to 20 mM in DMSO
>98 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Rueter et al (2004) ABT-089: pharmacological properties of a neuronal nicotinic acetylcholine receptor agonist for the potential treatment of cognitive disorders. CNS Drug Rev. 10 167. PMID: 15179445.

Decker et al (1997) ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A novel cholinergic channel modulator with effects on cognitive performance in rats and monkeys. J.Pharmacol.Exp.Ther. 283 247. PMID: 9336330.

Sullivan et al (1997) ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties. J.Pharmacol.Exp.Ther. 283 235. PMID: 9336329.

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