DDR1-IN-1 dihydrochloride

Cat. No. 5077

DDR1-IN-1 dihydrochloride C30H31F3N4O3.2HCl

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Chemical Name: N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide dihydrochloride

Biological Activity

Selective discoidin domain receptor 1 (DDR1) tyrosine kinase inhibitor (IC50 values are 105 and 413 nM for DDR1 and DDR2 respectively). Inhibits integrin-induced DDR1 autophosphorylation in an osteosarcoma cell line.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of DDR1-IN-1 is reviewed on the chemical probes website.

Technical Data

M.Wt:
625.51
Formula:
C30H31F3N4O3.2HCl
Solubility:
Soluble to 100 mM in water and to 50 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Canning et al (2014) Structural Mechanisms Determining Inhibition of the Collagen Receptor DDR1 by Selective and Multi-Targeted Type II Kinase Inhibitors. J.Mol.Biol. 426 2457. PMID: 24768818.

Kim et al (2013) Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor. ACS.Chem.Biol. 8 2145. PMID: 23899692.

If you know of a relevant reference for DDR1-IN-1 dihydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for DDR1-IN-1 dihydrochloride include:

Malaguarnera et al (2015) Novel cross talk between IGF-IR and DDR1 regulates IGF-IR trafficking, signaling and biological responses. BMC Complement Altern Med 6 16084. PMID: 25840417.

Do you know of a great paper that uses DDR1-IN-1 dihydrochloride from Tocris? If so please let us know.

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Keywords: DDR1-IN-1 dihydrochloride, supplier, selective, discoidin, domain, receptors, DDR1, DDR2, tyrosine, kinases, Tocris Bioscience, Other RTKs Inhibitor products

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