Cat. No. 5076
Chemical Name: 3-(2-Benzothiazolyl)-6-ethyl-7-hydr
Biological ActivitySkp2 inhibitor; thought to prevent assembly of Skp2-Skp1 complexes. Selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. Also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. Suppresses the survival of cancer cells and cancer stem cells by triggering cell senescence and inhibiting glycolysis. Exhibits antitumor effects in multiple animal models and cancer cell lines.
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Certificate of Analysis / Product Datasheet / Safety Data Sheet
Chan et al (2013) Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell 154 556. PMID: 23911321 .
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Keywords: SZL P1-41, supplier, SZLP1-41, Selective, Skp2, inhibitors, inhibits, suppresses, E3, ligase, SCF, complexes, antitumor, p27, Akt, ubiquitination, cell, senescence, glycolysis, Tocris Bioscience, Ubiquitin E3 Ligase Inhibitor products