ITD 1

Cat. No. 5068

ITD 1 C27H29NO3 [1099644-42-4]

Price and Availability

For ITD 1 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 4-[1,1'-Biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-3-quinolinecarboxylic acid ethyl ester

Biological Activity

Selective inhibitor of TGF-β signaling (IC50 = 0.85 μM); displays little or no inhibition of activin, Wnt or BMP signaling pathways. Induces proteasomal degradation of the TGF-β type II receptor. Inhibits TGF-β-induced mesoderm formation from mouse embryonic stem cells (ESCs) during early differentiation; selectively promotes the differentiation of ESCs to cardiomyocytes in vitro between days 3-5. Does not induce differentiation of vascular smooth muscle cells or endothelial cells.

Technical Data

M.Wt:
415.52
Formula:
C27H29NO3
Solubility:
Soluble to 20 mM in DMSO and to 10 mM in ethanol with gentle warming
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1099644-42-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Kinney et al (2013) Emerging strategies for spatiotemporal control of stem cell fate and morphogenesis. Trends Biotechnol. 31 78. PMID: 23219200.

Willems et al (2012) Small molecule-mediated TGF- type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell 11 242. PMID: 22862949.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses ITD 1 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: ITD 1, supplier, ITD1, selective, tgf-beta, tgf-b, tgf-β, signaling, pathway, inhibitors, inhibits, embryonic, stem, cells, cardiogenesis, cardiomyocytes, Tocris Bioscience, TGF-β Receptor products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

Kinases Product Listing

Kinases Product Listing

Our Kinase listing highlights over 400 products for kinase research. Request copy or view PDF today.

divider line

Immunology Guide

Immunology Product Listing

Our Immunology listing highlights over 190 products for immunology research. Request copy or view PDF today.

divider line

Stem Cell Toolbox

80 Stem Cell modulators supplied pre-dissolved in DMSO

Tocriscreen Stem Cell  Toolbox

Includes many of the latest compounds available for stem cell research. Covers compounds for stem cell differentiation, signaling and reprogramming.

divider line

Stem Cells Review

Written by K. Clarke et al

Stem Cells Scientific Review

Our Stem Cells review gives an overview of the use of small molecules in the control of stem cell growth & differentiation and somatic cell reprogramming. Request copy or view PDF today.

divider line

TGF-β Pathway

TGF-β  Signaling Pathway

TGF-β signaling is involved in the regulation of growth and proliferation of cells along with migration, differentiation and apoptosis. View pathway or download PDF today.

divider line

New Products in this Area

LDN 193189 dihydrochloride

Potent and selective ALK2 and ALK3 inhibitor; promotes neural induction of hPSCs

Sign-up for new product e-alerts
divider line

Bio-Techne Events

BNA festival

BNA 2017 Festival of Neuroscience

April 10 - 13, 2017

Birmingham, UK

Booth: 40