ITD 1

Cat. No. 5068

ITD 1 C27H29NO3 [1099644-42-4]

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Chemical Name: 4-[1,1'-Biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-3-quinolinecarboxylic acid ethyl ester

Biological Activity

Selective inhibitor of TGF-β signaling (IC50 = 0.85 μM); displays little or no inhibition of activin, Wnt or BMP signaling pathways. Induces proteasomal degradation of the TGF-β type II receptor. Inhibits TGF-β-induced mesoderm formation from mouse embryonic stem cells (ESCs) during early differentiation; selectively promotes the differentiation of ESCs to cardiomyocytes in vitro between days 3-5. Does not induce differentiation of vascular smooth muscle cells or endothelial cells.

Technical Data

M.Wt:
415.52
Formula:
C27H29NO3
Solubility:
Soluble to 20 mM in DMSO and to 10 mM in ethanol with gentle warming
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1099644-42-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Kinney et al (2013) Emerging strategies for spatiotemporal control of stem cell fate and morphogenesis. Trends Biotechnol. 31 78. PMID: 23219200.

Willems et al (2012) Small molecule-mediated TGF- type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell 11 242. PMID: 22862949.

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Keywords: ITD 1, supplier, ITD1, selective, tgf-beta, tgf-b, tgf-β, signaling, pathway, inhibitors, inhibits, embryonic, stem, cells, cardiogenesis, cardiomyocytes, Tocris Bioscience, TGF-β Receptor products

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