MRT 68601 hydrochloride
Cat. No. 5067
Chemical Name: N-[3-[[5-Cyclopropyl-2-[[4-(4-morph
Biological ActivityPotent TBK1 (TANK-binding kinase-1) inhibitor (IC50 = 6 nM). Inhibits the formation of autophagosomes in lung cancer cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
McIver et al (2012) Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKe kinases. Bioorg.Med.Chem.Lett. 22 7169. PMID: 23099093.
Newman et al (2012) TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-κB signalling. PLoS ONE 7 e50672. PMID: 23209807.
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Keywords: MRT 68601 hydrochloride, supplier, MRT68601, hydrochloride, potent, TBK1, TANK-binding, kinase-1, inhibitors, inhibits, autophagy, autophagosomes, Tocris Bioscience, Other Kinase Inhibitor products
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