NSC 319726

Cat. No. 5065

NSC 319726 C11H14N4S [71555-25-4]

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Chemical Name: 1-Azetidinecarbothioic acid [1-(2-pyridinyl)ethylidene]hydrazide

Biological Activity

Reactivator of mutant p53. Restores wild type p53 structure and function to the p53R175 mutant. Inhibits growth of fibroblasts expressing the p53R175 mutation (IC50 = 8 nM). Also inhibits growth of xenograft tumors expressing the p53R175 mutation in vivo.

Technical Data

M.Wt:
234.32
Formula:
C11H14N4S
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
71555-25-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Yu et al (2012) Allele-specific p53 mutant reactivation. Cancer Cell 21 614. PMID: 22624712.

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Keywords: NSC 319726, supplier, NSC319726, mutant, p53, reactivators, activators, p53R175, transcription, factors, cell, cycle, apoptosis, Tocris Bioscience, p53 Activator products

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