SRPIN340

Cat. No. 5063

SRPIN340 C18H18F3N3O [218156-96-8]

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Chemical Name: N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide

Biological Activity

Selective serine arginine protein kinase (SRPK) 1 inhibitor (Ki = 0.89 μM). Inhibits SRPK2 at higher concentrations. Does not significantly inhibit other SRPKs such as CLK1 and CLK4, or other classes of SR kinases. Down-regulates expression of VEGF165 but does not affect VEGF165b expression.

Technical Data

M.Wt:
349.35
Formula:
C18H18F3N3O
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
218156-96-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Gammons et al (2013) SRPK1 inhibition modulates VEGF splicing to reduce pathological neovascularization in a rat model of retinopathy of prematurity. Invest.Ophthalmol.Vis.Sci. 54 5797. PMID: 23761094.

Oltean et al (2012) SRPK1 inhibition in vivo: modulation of VEGF splicing and potential treatment for multiple diseases. Biochem.Soc.Trans. 40 831. PMID: 22817743.

Fukuhara et al (2006) Utilization of host SR protein kinases and RNA-splicing machinery during viral replication. Proc.Natl.Acad.Sci.USA 103 11329. PMID: 16840555.

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Keywords: SRPIN340, supplier, SR, Protein, Kinase, inhibitors, Phosphorylation, Inhibitor, 340(SRPIN)340, Serine-Arginine-Rich, Protein, inhibits, SRPK1, SRPK2, Tocris Bioscience, Other Kinase Inhibitor products

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