UNC 2327

Cat. No. 5057

UNC 2327 C14H17N5O2S [1426152-53-5]

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Chemical Name: N-1,2,3-Benzothiadiazol-6-yl-N'-[2-oxo-2-(1-piperidinyl)ethyl]urea

Biological Activity

Allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50 = 230 nM). Noncompetitive with both the peptide substrate and cofactor.

Technical Data

Soluble to 100 mM in DMSO
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Liu et al (2013) Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors. J.Med.Chem. 56 2110. PMID: 23445220.

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Keywords: UNC 2327, supplier, UNC2327, Allosteric, inhibitors, inhibits, protein, arginine, methyltransferases, 3, PRMT3, Tocris Bioscience, Protein Arginine Methyltransferase Inhibitor products

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