Ki 16425

Cat. No. 5056

Ki 16425 C23H23ClN2O5S [355025-24-0]

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Chemical Name: 3-[[[4-[4-[[[1-(2-Chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]phenyl]methyl]thio]propanoic acid

Biological Activity

Antagonist of the lysophosphatidic acid receptors LPA1 and LPA3 (Ki values are 0.25 and 0.36 μM respectively, in a GTPγS binding assay). Blocks LPA-induced dephosphorylation of Yes-associated protein (YAP) and WW domain-containing transcription regulator protein 1 (TAZ), inhibiting the Hippo signaling pathway, in HEK293A cells.

Technical Data

M.Wt:
474.96
Formula:
C23H23ClN2O5S
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in 1eq. NaOH
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
355025-24-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Yu et al (2012) Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell 150 780. PMID: 22863277.

Yamada et al (2004) Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1. J.Biol.Chem. 279 6595. PMID: 14660630.

Ohta et al (2003) Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors. Mol.Pharmacol. 64 994. PMID: 14500756.

If you know of a relevant reference for Ki 16425 please let us know.

Citations are publications that use Tocris products. Selected citations for Ki 16425 include:

Evseenko et al (2013) Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment. PLoS One 8 e63718. PMID: 23696850.

Do you know of a great paper that uses Ki 16425 from Tocris? If so please let us know.

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Keywords: Ki 16425, supplier, Ki16425, lysophosphatidic, acid, receptors, LPA1, LPA2, LPA3, YAP, TAZ, HIPPO, Tocris Bioscience, Lysophosphatidic Acid Receptor Antagonist products

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