Cat. No. 5053
Chemical Name: 4-[4,4-Difluoro-1-(2-fluorophenyl)c
Biological ActivityPotent and selective ERβ agonist (EC50 values are 6 and 5000 nM for ERβ and ERα respectively). Exhibits gender selective neuroprotective effects in a male rat model of Parkinson's disease. Decreases Aβ levels in combination with ACP-105 in a rat model of Alzheimer's disease.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
George et al (2013) Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer's disease. ACS Chem.Neurosci. 4 1537. PMID: 24020966.
McFarland et al (2013) AC-186, a selective nonsteroidal estrogen receptor β agonist, shows gender specific neuroprotection in a Parkinson's disease rat model. ACS Chem.Neurosci. 4 1249. PMID: 23898966.
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Keywords: AC 186, supplier, AC186, potent, selective, estrogen, receptors, ERbeta, ERb, ERβ, neuroprotection, neuroprotective, parkinsons, alzheimers, parkinson's, alzheimer's, Ab, Abeta, Aβ, amyloidbeta, amyloidb, amyloidβ, Tocris Bioscience, Estrogen and Related Receptor Agonist products