AC 186

Cat. No. 5053

AC 186 C18H17F3O [1421854-16-1]

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Chemical Name: 4-[4,4-Difluoro-1-(2-fluorophenyl)cyclohexyl]phenol

Biological Activity

Potent and selective ERβ agonist (EC50 values are 6 and 5000 nM for ERβ and ERα respectively). Exhibits gender selective neuroprotective effects in a male rat model of Parkinson's disease. Decreases Aβ levels in combination with ACP-105 in a rat model of Alzheimer's disease.

Technical Data

M.Wt:
306.32
Formula:
C18H17F3O
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
1421854-16-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

George et al (2013) Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer's disease. ACS Chem.Neurosci. 4 1537. PMID: 24020966.

McFarland et al (2013) AC-186, a selective nonsteroidal estrogen receptor β agonist, shows gender specific neuroprotection in a Parkinson's disease rat model. ACS Chem.Neurosci. 4 1249. PMID: 23898966.

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Citations are publications that use Tocris products.

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Keywords: AC 186, supplier, AC186, potent, selective, estrogen, receptors, ERbeta, ERb, ERβ, neuroprotection, neuroprotective, parkinsons, alzheimers, parkinson's, alzheimer's, Ab, Abeta, Aβ, amyloidbeta, amyloidb, amyloidβ, Tocris Bioscience, Estrogen and Related Receptor Agonist products

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