BIO 5192

Cat. No. 5051

BIO 5192 C38H46Cl2N6O8S [327613-57-0]

Price and Availability

For BIO 5192 pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: (2S)-2-[[[(2S)-1-[(3,5-Dichlorophenyl)sulfonyl]-2-pyrrolidinyl]carbonyl]amino]-4-[[(2S)-4-methyl-2-[methyl[2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]amino]-1-oxopentyl]amino]butanoic acid

Biological Activity

Highly selective and potent inhibitor of integrin α4β1 (Very Late Antigen-4; VLA-4) (Kd < 10 pM). Selectively binds α4β1 over a range of other integrins (IC50 values are 1.8, 138, 1053, > 500 and > 10,000 nM for α4β1, α9β1, α2β1, α4β7 and αIIbβ3, respectively). Induces a 30-fold increase in mobilization of murine hematopoietic stem and progenitor cells; displays a 3-fold additive effect with AMD 3100 (Cat. No. 3299).

Technical Data

Soluble to 100 mM in DMSO and to 50 mM in 1eq. NaOH
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Ramirez et al (2009) BIO5192, a small molecule inhibitor of VLA-4, mobilizes hematopoietic stem and progenitor cells. Blood. 1340 1340. PMID: 19571319.

Xu et al (2008) A chemical approach to stem-cell biology and regenerative medicine. Nature 453 338. PMID: 18480815.

Leone et al (2003) An assessment of the mechanistic differences between two integrin α4β1 inhibitors, the monoclonal antibody TA-2 and the small molecule BIO5192, in rat experimental autoimmune encephalomyelitis. J.Pharmacol.Exp.Ther. 305 1150. PMID: 12626659.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses BIO 5192 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: BIO 5192, supplier, BIO5192, Inflammatory, mobilization, hematopoietic, stem, progenitors, AMD3100, plerixafor, HSPCs, highly, selective, potent, inhibitor, of, integrin, ⓮⓵, VLA-4, Very, Late, Antigen, 4, mobilisation, haematopoietic, inhibitors, inhibits, Tocris Bioscience, Integrin Receptor Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Immunology Guide

Immunology Product Listing

Our Immunology listing highlights over 190 products for immunology research. Request copy or view PDF today.

divider line

New Products in this Area


Potent and selective inhibitor of integrins αvβ3 and αvβ5

SM 324405

Potent TLR7 agonist

RS 09

TLR4 peptide agonist; acts as an adjuvant in vivo

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.