Cat. No. 5050
Chemical Name: 2-[(2,3,4,9-Tetrahydro-6-phenyl-1H-
Biological ActivityCdc42 GTPase inhibitor (IC50 = 2 μM). Reduces active levels of Cdc42 in aged hematopoietic stem cells (HSCs) to that in young HSCs. Reverses the aging-related and polarity phenotype of aged HSCs to that of young HSCs in vivo. Increases histone H4K16 acetylation in aged HSCs.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Li et al (2013) Chemical approaches to stem cell biology and therapeutics. Cell Stem Cell 13 270. PMID: 24012368.
Florian et al (2012) Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. Cell Stem Cell 10 520. PMID: 22560076.
Peterson et al (2006) Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components. Chem.Biol. 13 443. PMID: 16632257.
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Citations are publications that use Tocris products. Selected citations for CASIN include:
Cheng et al (2011) Biphasic effect of nitric oxide on the cardiac voltage-dependent anion channel. FEBS Lett 585 328. PMID: 21156174.
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Keywords: CASIN, supplier, Cdc42, GTPase, inhibitors, inhibits, hematopoietic, stem, cells, HSCs, aged, young, stem, cell, signaling, Tocris Bioscience, G Protein (Small) Inhibitor products
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