Cat. No. 5048
Chemical Name: Ethyl 7-hydroxy-2-oxo-2H-1-benzopyran-3-c
Biological ActivityPFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor (IC50 = 0.183 μM). Also competitively inhibits F-6-P (Ki = 0.094 μM). Inhibits cell growth (GI50 = 2.7 μM) in a XTT-based in vitro toxicology assay.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Seo et al (2011) Structure-based development of small molecule PFKFB3 inhibitors: a framework for potential cancer therapeutic agents targeting the Warburg effect. PLoS One 6 e24179. PMID: 21957443.
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Keywords: YZ9, supplier, PFKFB3, inhibitors, inhibits, phosphofructo, kinase, fructose, bifunctional, enzymes, growth, cancer, glycolysis, warburg, Tocris Bioscience, PFKFB3 Inhibitor products
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