Cat. No. 5045

L002 C15H15NO5S [321695-57-2]

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Chemical Name: 4-[O-[(4-Methoxyphenyl)sulfonyl]oxime]-2,6-dimethyl-2,5-cyclohexadiene-1,4-dione

Biological Activity

p300 inhibitor (IC50 = 1.98 μM). Inhibits histone and p53 acetylation, and suppresses STAT3 activation in cell-based assays. Also suppresses tumor growth in a mouse MDA-MB-468 xenograft model.

Technical Data

Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Yang et al (2013) Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents. Mol.Cancer Ther. 12 610. PMID: 23625935.

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Keywords: L002, supplier, p300, EP300, lysine, histone, acetyltransferases, inhibitors, inhibits, HATs, anticancer, Tocris Bioscience, Histone Acetyltransferase Inhibitor products

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