Cat. No. 5045
Chemical Name: 4-[O-[(4-Methoxyphenyl)sulfonyl]oxi
Biological Activityp300 inhibitor (IC50 = 1.98 μM). Inhibits histone and p53 acetylation, and suppresses STAT3 activation in cell-based assays. Also suppresses tumor growth in a mouse MDA-MB-468 xenograft model.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Yang et al (2013) Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents. Mol.Cancer Ther. 12 610. PMID: 23625935.
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Keywords: L002, supplier, p300, EP300, lysine, histone, acetyltransferases, inhibitors, inhibits, HATs, anticancer, Tocris Bioscience, Histone Acetyltransferase Inhibitor products
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