Cat. No. 5045
Chemical Name: 4-[O-[(4-Methoxyphenyl)sulfonyl]oxi
Biological Activityp300 inhibitor (IC50 = 1.98 μM). Inhibits histone and p53 acetylation, and suppresses STAT3 activation in cell-based assays. Also suppresses tumor growth in a mouse MDA-MB-468 xenograft model.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Yang et al (2013) Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents. Mol.Cancer Ther. 12 610. PMID: 23625935.
If you know of a relevant reference for L002 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses L002 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: L002, supplier, p300, EP300, lysine, histone, acetyltransferases, inhibitors, inhibits, HATs, anticancer, Tocris Bioscience, Histone Acetyltransferase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Histone H3 peptideTC AC 28
High affinity BET bromodomain ligandTP 472N
Negative control for TP 472 (Cat. No. 6000).TP 472
Potent BRD9/7 inhibitorBAY 299
Potent and selective BRD1 and TAF1 inhibitor
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.