L002

Cat. No. 5045

L002 C15H15NO5S [321695-57-2]

Price and Availability

For L002 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 4-[O-[(4-Methoxyphenyl)sulfonyl]oxime]-2,6-dimethyl-2,5-cyclohexadiene-1,4-dione

Biological Activity

p300 inhibitor (IC50 = 1.98 μM). Inhibits histone and p53 acetylation, and suppresses STAT3 activation in cell-based assays. Also suppresses tumor growth in a mouse MDA-MB-468 xenograft model.

Technical Data

M.Wt:
321.35
Formula:
C15H15NO5S
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
321695-57-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Yang et al (2013) Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents. Mol.Cancer Ther. 12 610. PMID: 23625935.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses L002 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: L002, supplier, p300, EP300, lysine, histone, acetyltransferases, inhibitors, inhibits, HATs, anticancer, Tocris Bioscience, Histone Acetyltransferase Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Epigenetics Toolbox

80 Epigenetic modulators supplied pre-dissolved in DMSO

Tocriscreen Epigenetics Toolbox

Includes many of the latest compounds available for epigenetics research. Covers a wide range of targets, such as bromodomains, KMTs, PRMTs and HDACs.

divider line

Epigenetics Review

Written by S. Müller-Knapp & P. Brown

Epigenetics Scientific Review

Our Epigenetics review gives an overview of the development of chemical probes for epigenetic targets, and discusses their biological effects. Request copy or view PDF today.

divider line

Epigenetics Research Bulletin

The epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets. View PDF today.

divider line

New Products in this Area

TP 472

Potent BRD9/7 inhibitor

BAY 299

Potent and selective BRD1 and TAF1 inhibitor

NVS-CECR2-1

Potent and selective inhibitor of cat eye syndrome chromosome region, candidate 2 (CECR2)

NI 42

High affinity BRPF inhibitor

Sign-up for new product e-alerts
divider line

Bio-Techne Events

BNA festival

BNA 2017 Festival of Neuroscience

April 10 - 13, 2017

Birmingham, UK

Booth: 40