SR 3576

Cat. No. 5044

SR 3576 C27H27N5O5 [1164153-22-3]

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Chemical Name: 3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)benzamide

Biological Activity

Highly potent and selective JNK3 inhibitor (IC50 = 7 nM); exhibits > 2800-fold selectivity over p38.

Technical Data

Soluble to 100 mM in DMSO
>97 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Kamenecka et al (2009) Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38. J Biol Chem. 284 12853. PMID: 19261605.

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Keywords: SR 3576, supplier, SR3576, c-Jun, N-terminal, kinase, 3alpha1, JNK3alpha1, highly, potent, selective, inhibitors, inhibits, Tocris Bioscience, JNK/c-Jun Inhibitor products

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