ABT

Cat. No. 5038

ABT C6H6N4 [1614-12-6]

Price and Availability

For ABT pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 1H-Benzotriazol-1-amine

Biological Activity

Cytochrome P450 inhibitor. Inhibits synthesis of the eicosanoid 20-hydroxyeicosatetraenoic acid (20-HETE). Reduces intimal hyperplasia and vascular remodeling following endothelial injury in rat carotid arteries.

Technical Data

M.Wt:
134.14
Formula:
C6H6N4
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
1614-12-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Orozco et al (2013) 20-hydroxyeicosatetraenoic acid inhibition attenuates balloon injury-induced neointima formation and vascular remodeling in rat carotid arteries. J.Pharmacol.Exp.Ther. 346 67. PMID: 23658377.

Mathews et al (1985) Inactivation of rabbit pulmonary cytochrome P-450 in microsomes and isolated perfused lungs by the suicide substrate 1-aminobenzotriazole. J.Pharmacol.Exp.Ther. 235 186. PMID: 4045721.

If you know of a relevant reference for ABT please let us know.

Citations are publications that use Tocris products. Selected citations for ABT include:

Zhu and Gomez (2012) Further evidence for the role of IP 3R 1 in regulating subsynaptic gene expression and neuromuscular transmission. Pharmacol Res Perspect 6 65. PMID: 22418950.

Do you know of a great paper that uses ABT from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: ABT, supplier, cytochrome, p450, inhibitors, inhibits, cyp450, synthesis, 20-HETE, Tocris Bioscience, Cytochrome P450 Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

New Product Guide (Fall/Winter 2016)

Our New Product guide highlights over 100 new products added in the second half of 2016. Request copy or view PDF today.

divider line

New Products in this Area

7-Ethoxyresorufin

Fluorometric CYP450 substrate

Galeterone

CYP17 inhibitor; also androgen receptor antagonist

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.