Cat. No. 5038
Chemical Name: 1H-Benzotriazol-1-amine
Biological ActivityCytochrome P450 inhibitor. Inhibits synthesis of the eicosanoid 20-hydroxyeicosatetraenoic acid (20-HETE). Reduces intimal hyperplasia and vascular remodeling following endothelial injury in rat carotid arteries.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Orozco et al (2013) 20-hydroxyeicosatetraenoic acid inhibition attenuates balloon injury-induced neointima formation and vascular remodeling in rat carotid arteries. J.Pharmacol.Exp.Ther. 346 67. PMID: 23658377.
Mathews et al (1985) Inactivation of rabbit pulmonary cytochrome P-450 in microsomes and isolated perfused lungs by the suicide substrate 1-aminobenzotriazole. J.Pharmacol.Exp.Ther. 235 186. PMID: 4045721.
If you know of a relevant reference for ABT please let us know.
Citations are publications that use Tocris products. Selected citations for ABT include:
Zhu and Gomez (2012) Further evidence for the role of IP 3R 1 in regulating subsynaptic gene expression and neuromuscular transmission. Pharmacol Res Perspect 6 65. PMID: 22418950.
Do you know of a great paper that uses ABT from Tocris? If so please let us know.
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Keywords: ABT, supplier, cytochrome, p450, inhibitors, inhibits, cyp450, synthesis, 20-HETE, Tocris Bioscience, Cytochrome P450 Inhibitor products
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