Cat. No. 5035
Chemical Name: 2-Fluoro-4-[[[1,2,3,4-Tetrahydro-1-
Biological ActivitySelective free fatty acid receptor 1 (FFA1/GPR40) agonist. Exhibits selectivity for GPR40 over GPR41, GPR43, GPR119, GPR120 and PPARγ. Induces glucose-dependent insulin secretion in pancreatic MIN6 cells and in vivo. Enhances insulin sensitivity in a type 2 diabetes model in vivo. Orally available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Tanaka et al (2013) Chronic treatment with novel GPR40 agonists improve whole-body glucose metabolism based on the glucose-dependent insulin secretion. J.Pharmacol.Exp.Ther. 346 443. PMID: 23853170.
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Keywords: AS 2034178, supplier, AS2034178, selective, free, fatty, acid, receptors, FFA1, GPR40, agonists, diabetes, insulin, sensitivity, FFAR1, Tocris Bioscience, Free Fatty Acid Receptor Agonist products
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