Cat. No. 5032
Alternative Names: GYKI 53773, LY 300164
Chemical Name: (8R)-7-Acetyl-5-(4-aminophenyl)-8,9
Biological ActivityNon-competitive AMPA/kainate receptor antagonist that displays 2.3-3-fold more potent activity than GYKI 52466 (Cat. No. 1454). Potentiates the anticonvulsive activity of antiepileptic drugs in animal models of seizures. Orally active.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Belayev et al (2001) Talampanel, a novel noncompetitive AMPA antagonist, is neuroprotective after traumatic brain injury in rats. J.Neurotrauma 18 1031. PMID: 11686490.
Borowicz et al (2000) The AMPA/kainate receptor antagonist, LY 300164, increases the anticonvulsant effects of diazepam. Naunyn-Schmied.Arch.Pharmacol. 361 629. PMID: 10882038.
Czuczwar et al (1998) LY 300164, a novel antagonist of AMPA/kainate receptors, potentiates the anticonvulsive activity of antiepileptic drugs. Eur.J.Pharmacol. 359 103. PMID: 9832379 .
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Keywords: Talampanel, supplier, GYKI53773, LY300164, non-competitive, AMPA/Kainate, antagonists, Glutamate, Receptors, iGlur, Ionotropic, Tocris Bioscience, AMPA Receptor Antagonist products