GMQ hydrochloride

Cat. No. 5028

GMQ hydrochloride C10H11N5.HCl [5361-15-9]

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Chemical Name: N-(4-Methyl-2-quinazolinyl)-guanidine hydrochloride

Biological Activity

Selective opener of acid-sensing ion channel 3 (ASIC3) at pH 7.4. Alters the pH dependence of ASIC1a and ASIC1b; does not affect the activation curve of ASIC2a.

Technical Data

Soluble to 50 mM in DMSO and to 5 mM in water with gentle warming
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Alijevic and Kellenberger (2012) Subtype-specific modulation of acid-sensing ion channel (ASIC) function by 2-guanidine-4-methylquinazoline. J.Biol.Chem. 287 36059. PMID: 22948146.

Li et al (2010) ASIC3 channels integrate agmatine and multiple inflammatory signals through the nonproton ligand sensing domain. Mol.Pain 6 88. PMID: 21143836.

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Keywords: GMQ hydrochloride, supplier, Selective, opener, acid-sensing, ion, channel, 3, ASIC3, ASIC1a, ASIC1b, Tocris Bioscience, Acid-Sensing Ion Channel Activator products

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