Cat. No. 5028
Chemical Name: N-(4-Methyl-2-quinazolinyl)-guanidi
Biological ActivitySelective opener of acid-sensing ion channel 3 (ASIC3) at pH 7.4. Alters the pH dependence of ASIC1a and ASIC1b; does not affect the activation curve of ASIC2a.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Alijevic and Kellenberger (2012) Subtype-specific modulation of acid-sensing ion channel (ASIC) function by 2-guanidine-4-methylquinazoline. J.Biol.Chem. 287 36059. PMID: 22948146.
Li et al (2010) ASIC3 channels integrate agmatine and multiple inflammatory signals through the nonproton ligand sensing domain. Mol.Pain 6 88. PMID: 21143836.
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Keywords: GMQ hydrochloride, supplier, Selective, opener, acid-sensing, ion, channel, 3, ASIC3, ASIC1a, ASIC1b, Tocris Bioscience, Acid-Sensing Ion Channel Activator products