Cat. No. 5027
Chemical Name: 2-Aminobicyclo[2.2.1]heptane-2-carb
Biological ActivityInhibitor of L-type amino acid transporter LAT1. Suppresses growth and induces apoptosis via activation of caspases in KB, Saos2 and C6 cancer cell lines.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Kim et al (2008) BCH, an inhibitor of system L amino acid transporters, induces apoptosis in cancer cells. Biol.Pharm.Bull. 31 1096. PMID: 18520037.
Lin et al (2004) L-type amino acid transporter-1 overexpression and melphalan sensitivity in Barrett's adenocarcinoma. Neoplasia 6 74. PMID: 15068672.
Fraga et al (2002) L-type amino acid transporters in two intestinal epithelial cell lines function as exchangers with neutral amino acids. J.Nutr. 132 733. PMID: 11925469.
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Keywords: BCH, supplier, LAT1, L-type, amino, acid, transporters, inhibitors, inhibits, Tocris Bioscience, Other Ion Pumps/Transporter Inhibitor products