Cat. No. 5027
Chemical Name: 2-Aminobicyclo[2.2.1]heptane-2-carb
Biological ActivityInhibitor of L-type amino acid transporter LAT1. Suppresses growth and induces apoptosis via activation of caspases in KB, Saos2 and C6 cancer cell lines.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kim et al (2008) BCH, an inhibitor of system L amino acid transporters, induces apoptosis in cancer cells. Biol.Pharm.Bull. 31 1096. PMID: 18520037.
Lin et al (2004) L-type amino acid transporter-1 overexpression and melphalan sensitivity in Barrett's adenocarcinoma. Neoplasia 6 74. PMID: 15068672.
Fraga et al (2002) L-type amino acid transporters in two intestinal epithelial cell lines function as exchangers with neutral amino acids. J.Nutr. 132 733. PMID: 11925469.
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Keywords: BCH, supplier, LAT1, L-type, amino, acid, transporters, inhibitors, inhibits, Tocris Bioscience, Other Ion Pumps/Transporter Inhibitor products
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