Cat. No. 5027

BCH C8H13NO2 [20448-79-7]

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Chemical Name: 2-Aminobicyclo[2.2.1]heptane-2-carboxylic acid

Biological Activity

Inhibitor of L-type amino acid transporter LAT1. Suppresses growth and induces apoptosis via activation of caspases in KB, Saos2 and C6 cancer cell lines.

Technical Data

Soluble to 100 mM in water
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Kim et al (2008) BCH, an inhibitor of system L amino acid transporters, induces apoptosis in cancer cells. Biol.Pharm.Bull. 31 1096. PMID: 18520037.

Lin et al (2004) L-type amino acid transporter-1 overexpression and melphalan sensitivity in Barrett's adenocarcinoma. Neoplasia 6 74. PMID: 15068672.

Fraga et al (2002) L-type amino acid transporters in two intestinal epithelial cell lines function as exchangers with neutral amino acids. J.Nutr. 132 733. PMID: 11925469.

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Keywords: BCH, supplier, LAT1, L-type, amino, acid, transporters, inhibitors, inhibits, Tocris Bioscience, Other Ion Pumps/Transporter Inhibitor products

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