Cat. No. 5021
Chemical Name: 4-(6,7-Dihydro-1,3-dimethylbenzo[c]
Biological ActivityPotent and selective α2D-adrenoceptor agonist (Ki values are 8.6 pM and 110 nM for rat α2D and α1 receptors respectively and 25, 26 and 100 nM for human α2A, α2C and α2B receptors respectively. Exhibits analgesic activity in a mouse model of abdominal irritation. Orally active.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Ross et al (2000) α2 adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-Imidazo)-1,3-dimethyl-6,7-dihydrothianaphthene as a high-affinity ligand for the α2D adrenergic receptor. J.Med.Chem. 43 1423. PMID: 10715142.
If you know of a relevant reference for TC-G 1000 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses TC-G 1000 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: TC-G 1000, supplier, TC-G1000, potent, selective, adrenergic, receptors, agonists, alpha2d, alpha1, alpha2a, alpha2b, alpha2c, α2d, α2a, α1, α2b, α2c, adrenoceptors, Tocris Bioscience, Adrenergic α2 Receptor Agonist products
Find multiple products by catalog number
New Products in this Area
Long-acting β2 agonist (LABA)
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.