Cat. No. 5020
Chemical Name: N-(9,10-Dihydro-9,10-dioxo-2-phenan
Biological ActivityPTEN inhibitor. Increases fMLP-elicited PIP3 signaling, Akt -phosphorylation and production of reactive oxygen species in neutrophils in vitro. Pretreatment of transfused neutrophils enhances chemotaxis to sites of bacterial infection and increases survival in neutropenic mice.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
Li (2011) Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. Blood 117 6702. PMID: 21521784.
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Keywords: SF 1670, supplier, SF1670, PTEN, inhibitors, phosphatase, tensin, homolog, deleted, chromosome, 10, neutrophils, transfusion, inhibits, Tocris Bioscience, Protein Tyrosine Phosphatases Inhibitor products