Cat. No. 5020
Chemical Name: N-(9,10-Dihydro-9,10-dioxo-2-phenan
Biological ActivityPTEN inhibitor. Increases fMLP-elicited PIP3 signaling, Akt -phosphorylation and production of reactive oxygen species in neutrophils in vitro. Pretreatment of transfused neutrophils enhances chemotaxis to sites of bacterial infection and increases survival in neutropenic mice.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Li (2011) Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. Blood 117 6702. PMID: 21521784.
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Keywords: SF 1670, supplier, SF1670, PTEN, inhibitors, phosphatase, tensin, homolog, deleted, chromosome, 10, neutrophils, transfusion, inhibits, Tocris Bioscience, Protein Tyrosine Phosphatases Inhibitor products