A 85380 dihydrochloride

Cat. No. 5017

A 85380 dihydrochloride C9H12N2O.2HCl [174740-86-4]

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Chemical Name: 3-[(2S)-2-Azetidinylmethoxy]-pyridine dihydrochloride

Biological Activity

High affinity and selective α4β2 nACh receptor agonist (Ki values are 0.05, 148 and 314 nM for α4β2, α7 and α1β1δγ receptors respectively). Stimulates cation efflux in K177 cells expressing α4β2.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>98 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Abreo et al (1996) Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors. J.Med.Chem. 39 817. PMID: 8632405.

Sullivan et al (1996) A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity α4β2 nicotinic acetylcholine receptor ligand. Neuropharmacology 35 725. PMID: 8887981.

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Keywords: A 85380 dihydrochloride, supplier, A85380, dihydrochloride, high, affinity, selective, nicotinic, receptors, cholinergic, acetylcholine, alpha4beta2, a4b2, α4β2, agonists, Tocris Bioscience, Nicotinic (α4β2) Receptor Agonist products

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