Cat. No. 5016
Chemical Name: 2-(3,4-Dihydroxyphenyl)-3,7-dihydro
Biological ActivityNaturally occuring flavonoid and antioxidant. Inhibits PI 3-K, Akt, mTOR and Cdk6. Displays antiproliferative activity in prostate cancer cells. Shown to activate ERK; exhibits neuroprotective activity in Huntington's disease models. Also a DNMT1 inhibitor.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Adhami et al (2012) Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management. Biochem.Pharmacol. 84 1277. PMID: 22842629.
Maher et al (2011) ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease. Hum.Mol.Genet. 20 261. PMID: 20952447.
Haddad et al (2010) Antiproliferative mechanisms of the flavonoids 2,2'-dihydroxychalcone and fisetin in human prostate cancer cells. Nutr.Cancer 62 668. PMID: 20574928.
Lee et al (2005) Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids. Mol.Pharmacol. 68 1018. PMID: 16037419.
Lu et al (2005) Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin. J.Med.Chem. 48 737. PMID: 15689157.
If you know of a relevant reference for Fisetin please let us know.
Citations are publications that use Tocris products. Selected citations for Fisetin include:
Kim et al (2016) Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors. PLoS Pathog 6 24933. PMID: 27112200.
Do you know of a great paper that uses Fisetin from Tocris? If so please let us know.
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Keywords: Fisetin, supplier, flavonoids, antioxidants, inhibitors, inhibits, PI, 3-K, kinase, Akt, mTOR, Cdk6, antiproliferative, cancer, activates, ERK, neuroprotective, Huntington's, DNA, Methyltransferases, DNMT, Tocris Bioscience, Antioxidant products
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