Cat. No. 5013
Chemical Name: N-[4-[[[[5-(1,1-Dimethethylethyl)-3
Biological ActivityPotent PDGFR family inhibitor (IC50 values are 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFRβ and CSF1R respectively; Kd = 1.3 nM for PDGFRα). Exhibits >30-fold selectivity over a panel of other kinases and exhibits no activity against cytochrome P450. Causes tumor regression of leukemia cell xenografts in mice. Also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis. Orally active.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Liu et al (2012) Discovery of AC710, a globally selective inhibitor of platelet-derived growth factor receptor-family kinases. ACS Med.Chem.Lett. 3 997. PMID: 24900421.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses AC 710 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: AC 710, supplier, AC710, potent, PDGFR, platelet, derived, growth, factor, receptors, family, inhibitors, inhibits, KIT, FLT3, PDGFRalpha, PDGFRa, PDGFRα, PDGFRbeta, PDGFRb, PDGFRβ, CSFR1, antitumor, arthritis, FMS-like, tyrosine, kinases, c-fms, M-CSFR, Tocris Bioscience, PDGFR Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent and selective PDGFR inhibitorGSK 1363089
Potent inhibitor of MET, VEGFR2, Ron and AXLPF 06273340
Potent and selective pan-Trk inhibitor; peripherally restricted
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.