PCI 29732

Cat. No. 5012

PCI 29732 C22H21N5O [330786-25-9]

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Chemical Name: 1-Cyclopentyl-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Biological Activity

Potent BTK inhibitor (IC50 = 0.3 nM). Blocks B cell antigen receptor (BCR)-mediated gene expression in CD20+ B cells.

Technical Data

M.Wt:
371.44
Formula:
C22H21N5O
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
330786-25-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Krishnamurty et al (2013) Active site profiling reveals coupling between domains in SRC-family kinases. Nat.Chem.Biol. 9 43. PMID: 23143416.

Honigberg et al (2010) The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc.Natl.Acad.Sci.U.S.A. 107 13075. PMID: 20615965.

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Citations are publications that use Tocris products.

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Keywords: PCI 29732, supplier, PCI29732, Tocris Bioscience, Bruton's Tyrosine Kinase Inhibitor products

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