HMR 1556

Cat. No. 5011

HMR 1556 C17H24F3NO5S [223749-46-0]

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Chemical Name: N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide

Biological Activity

Potent and selective Iks channel blocker (IC50 values are 10.5 and 34 nM in canine and guinea pig ventricular myocytes respectively). Selectively inhibits IKs currents over IKr, IKI, Ito and L-type Ca2+ channel currents. Also has little or no effect on Kv11.1 Kv1.5, Kv1.3, Kir2.1 and HCN2 channel currents. Potentiates E-4031-induced arrhythmias in vivo.

Technical Data

M.Wt:
411.44
Formula:
C17H24F3NO5S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
223749-46-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Michael et al (2007) Potentiation of E-4031-induced torsade de pointes by HMR1556 or ATX-II is not predicted by action potential short-term variability or triangulation. Br.J.Pharmacol 152 1215. PMID: 17965747.

Thomas et al (2003) HMR 1556, a potent and selective blocker of slowly activating delayed rectifier potassium current. J.Cardiovasc.Pharmacol. 41 140. PMID: 12500032.

Gerlach et al (2001) Synthesis and activity of novel and selective I(Ks)-channel blockers. J.Med.Chem. 44 3831. PMID: 11689069.

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Keywords: HMR 1556, supplier, HMR1556, potent, selective, IKs, channels, blockers, blocks, cardiac, Kv7.1, potassium, K+, slow, delayed, rectifier, current, KCNQ1, voltage-gated, voltage-dependent, Tocris Bioscience, Voltage-gated Potassium (KV) Channel Blocker products

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