Hemokinin 1 (mouse)
Cat. No. 1535
Alternative Names: HK-1, HEK-1
Biological ActivityNovel mammalian endogenous peptide, homolog of substance P, that is a high affinity and selective agonist at the tachykinin NK1 receptor (Ki values are 0.175 and 560 nM for NK1 and NK2 receptors respectively). Has proliferative and antiapoptotic actions on B-cells in vitro and is antihypertensive in vivo.
(Modifications: Met-11 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Bellucci et al (2002) Pharmacological profile of the novel mammalian tachykinin hemokinin 1. Br.J.Pharmacol. 135 266. PMID: 11786503.
Morteau et al (2001) Hemokinin 1 is a full agonist at the substance P receptor. Nat.Immunol. 2 1088. PMID: 11725292.
Zhang et al (2000) Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis. Nat.Immunol. 1 392. PMID: 11062498.
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Keywords: Hemokinin 1 (mouse), supplier, Endogenous, high, affinity, selective, NK1, agonists, Tachykinin, Receptors, Neurokinin, Hemokinin1, (mouse), Tocris Bioscience, NK1 Receptor Agonist products