Cat. No. 4999
Chemical Name: 9-Hydroxyphenanthrene
Biological ActivitySelective TRPM4 blocker (IC50 = 20 μM in HEK293 cells). Exhibits no effect on CFTR or TRPM5 (at 0.25 and 1 mM respectively). Abolishes arrhythmias induced by hypoxia in a mouse heart model.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Simard et al (2012) Transient receptor potential melastatin 4 inhibitor 9-phenanthrol abolishes arrhythmias induced by hypoxia and re-oxygenation in mouse ventricle. Br.J.Pharmacol. 165 2354. PMID: 22014185.
Grand et al (2008) 9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels. Br.J.Pharmacol. 153 1697. PMID: 18297105.
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Keywords: 9-Phenanthrol, supplier, Transient, receptor, potential, TRPM4, blockers, TRP, channels, arrhythmias, cardiac, heart, anti-arrhythmic, depolarisations, Tocris Bioscience, TRPM Blocker products
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