Cat. No. 4999
Chemical Name: 9-Hydroxyphenanthrene
Biological ActivitySelective TRPM4 blocker (IC50 = 20 μM in HEK293 cells). Exhibits no effect on CFTR or TRPM5 (at 0.25 and 1 mM respectively). Abolishes arrhythmias induced by hypoxia in a mouse heart model.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Simard et al (2012) Transient receptor potential melastatin 4 inhibitor 9-phenanthrol abolishes arrhythmias induced by hypoxia and re-oxygenation in mouse ventricle. Br.J.Pharmacol. 165 2354. PMID: 22014185.
Grand et al (2008) 9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels. Br.J.Pharmacol. 153 1697. PMID: 18297105.
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Keywords: 9-Phenanthrol, supplier, Transient, receptor, potential, TRPM4, blockers, TRP, channels, arrhythmias, cardiac, heart, anti-arrhythmic, depolarisations, Tocris Bioscience, TRPM Blocker products
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