Cat. No. 4996
Chemical Name: 4-(2-Benzothiazolyl)-4-hydroxy-2,5-
Biological ActivityPutative inhibitor of the thioredoxin-thioredoxin reductase (Trx-TrxR) system. Shown to inhibit Trx and induce a G1/S block in HT29 cells; inhibits cell proliferation in various colorectal cancer cell lines and MCF7 cells. Also elicits an anti-inflammatory response in A549 cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Callister et al (2008) PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-κB-dependent proinflammatory activation of alveolar epithelial cells. Br.J.Pharmacol. 155 661. PMID: 18587424.
Mukherjee et al (2007) A cellular and molecular investigation of the action of PMX464, a putative thioredoxin inhibitor, in normal and colorectal cancer cell lines. Br.J.Pharmacol. 151 1167. PMID: 17572693.
Mukherjee et al (2005) Cytotoxic and antiangiogenic activity of AW464 (NSC 706704), a novel thioredoxin inhibitor: an in vitro study. Br.J.Cancer 92 350. PMID: 15655539.
If you know of a relevant reference for PMX 464 please let us know.
Citations are publications that use Tocris products. Selected citations for PMX 464 include:
Schroeder (2017) Targeting Thioredoxin-1 by dimethyl fumarate induces ripoptosome-mediated cell death Sci Rep 7 43168. PMID: 28233787.
Do you know of a great paper that uses PMX 464 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: PMX 464, supplier, PMX464, PMX_464, antiproliferative, thioredoxin, reductase, TrxR, Trx1, inhibitors, inhibits, cell, proliferation, Tocris Bioscience, Other Reductase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Irreversible TxrR inhibitorPemetrexed
High affinity dihydrofolate reductase inhibitor; also inhibits thymidylate synthase, GARFT and AICARTD9
Potent thioredoxin reductase (TxrR) inhibitorMK 386
Potent, selective human type 1 5α-reductase inhibitorCCF 642
Protein disulfide isomerase (PDI) inhibitor
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.