Cat. No. 4996
Chemical Name: 4-(2-Benzothiazolyl)-4-hydroxy-2,5-
Biological ActivityPutative inhibitor of the thioredoxin-thioredoxin reductase (Trx-TrxR) system. Shown to inhibit Trx and induce a G1/S block in HT29 cells; inhibits cell proliferation in various colorectal cancer cell lines and MCF7 cells. Also elicits an anti-inflammatory response in A549 cells.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Callister et al (2008) PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-κB-dependent proinflammatory activation of alveolar epithelial cells. Br.J.Pharmacol. 155 661. PMID: 18587424.
Mukherjee et al (2007) A cellular and molecular investigation of the action of PMX464, a putative thioredoxin inhibitor, in normal and colorectal cancer cell lines. Br.J.Pharmacol. 151 1167. PMID: 17572693.
Mukherjee et al (2005) Cytotoxic and antiangiogenic activity of AW464 (NSC 706704), a novel thioredoxin inhibitor: an in vitro study. Br.J.Cancer 92 350. PMID: 15655539.
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Keywords: PMX 464, supplier, PMX464, PMX_464, antiproliferative, thioredoxin, reductase, TrxR, Trx1, inhibitors, inhibits, cell, proliferation, Tocris Bioscience, Other Reductase Inhibitor products
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