PMX 464

Cat. No. 4996

PMX 464 C13H9NO2S [485842-97-5]

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Chemical Name: 4-(2-Benzothiazolyl)-4-hydroxy-2,5-cyclohexadien-1-one

Biological Activity

Putative inhibitor of the thioredoxin-thioredoxin reductase (Trx-TrxR) system. Shown to inhibit Trx and induce a G1/S block in HT29 cells; inhibits cell proliferation in various colorectal cancer cell lines and MCF7 cells. Also elicits an anti-inflammatory response in A549 cells.

Technical Data

M.Wt:
243.28
Formula:
C13H9NO2S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
485842-97-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Callister et al (2008) PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-κB-dependent proinflammatory activation of alveolar epithelial cells. Br.J.Pharmacol. 155 661. PMID: 18587424.

Mukherjee et al (2007) A cellular and molecular investigation of the action of PMX464, a putative thioredoxin inhibitor, in normal and colorectal cancer cell lines. Br.J.Pharmacol. 151 1167. PMID: 17572693.

Mukherjee et al (2005) Cytotoxic and antiangiogenic activity of AW464 (NSC 706704), a novel thioredoxin inhibitor: an in vitro study. Br.J.Cancer 92 350. PMID: 15655539.

If you know of a relevant reference for PMX 464 please let us know.

Citations are publications that use Tocris products. Selected citations for PMX 464 include:

Schroeder (2017) Targeting Thioredoxin-1 by dimethyl fumarate induces ripoptosome-mediated cell death Sci Rep 7 43168. PMID: 28233787.

Do you know of a great paper that uses PMX 464 from Tocris? If so please let us know.

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Keywords: PMX 464, supplier, PMX464, PMX_464, antiproliferative, thioredoxin, reductase, TrxR, Trx1, inhibitors, inhibits, cell, proliferation, Tocris Bioscience, Other Reductase Inhibitor products

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