Phortress

Cat. No. 4995

Phortress C20H23FN4OS.2HCl [328087-38-3]

Price and Availability

For Phortress pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: (2S)-2,6-Diamino-N-[4-(5-fluoro-2-benzothiazolyl)-2-methylphenyl]hexanamide dihydrochloride

Biological Activity

Prodrug of the antitumor agent 5F 203, which acts via binding to aryl hydrocarbon receptors. Induces expression of CYP1A1 and generates adducts in the DNA of sensitive MCF7 and IGROV-1 cells.

Technical Data

M.Wt:
459.41
Formula:
C20H23FN4OS.2HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
328087-38-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Bradshaw and Westwell (2004) The development of the antitumour benzothiazole prodrug, phortress, as a clinical candidate. Curr.Med.Chem. 11 1241. PMID: 15078163.

Leong et al (2004) In vitro, in vivo and in silico analyses of the antitumor activity of 2(-4-amino-3-methylphenyl)-5-fluorobenzothiazoles. Mol.Cancer Ther. 3 1565. PMID: 15634650.

Leong et al (2003) Antitumour 2-(4-aminophenyl)benzothiazoles generate DNA adducts in sensitive tumour cells in vitro and in vivo. Br.J.Cancer 88 470. PMID: 12569393.

Trapani et al (2003) DNA damage and cell cycle arrest induced by 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is attenuated by aryl hydrocarbon receptor deficient MCF-7 cells. Br.J.Cancer 88 599. PMID: 12592376.

If you know of a relevant reference for Phortress please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses Phortress from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: Phortress, supplier, antitumor, antitumour, cytotoxic, prodrug, aryl, hydrocarbon, receptors, AhRs, Tocris Bioscience, Aryl Hydrocarbon Receptor products

Quick Order

Find multiple products by catalog number

divider line

Nuclear Receptors Product Listing

Nuclear Receptors Product Listing

Our Nuclear Receptors Listing highlights over 150 products for nuclear receptors. Request copy or view PDF today.

divider line

New Products in this Area

Megestrol Acetate

Synthetic progesterone analog

C-DIM 12

Nurr1 activator; inhibits NF-κB-dependent gene expression

(S)-Equol

Potent estrogen receptor β (ERβ) agonist

Ailanthone

Potent inhibitor of androgen receptor (AR)

(±)-ML 209

RORγt inverse agonist; suppresses Th17 cell differentiation

AGN 193109

High affinity pan-RAR antagonist

SR 9243

Selective LXR inverse agonist

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.