Cat. No. 4994
Chemical Name: 1-(3-Chloro-4-fluorophenyl)-4-[(5-n
Biological ActivityUbiquitin-activating enzyme (E1) inhibitor. Blocks degradation of p53 and cyclin D3. Inhibits NF-κB activation and induces cell death associated with ER stress. Displays antitumor effects in a mouse model of leukemia.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Xu et al (2010) The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma. Blood 115 2251. PMID: 20075161.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses PYZD 4409 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: PYZD 4409, supplier, PYZD4409, ubiquitin-activating, enzyme, E1, inhibitors, inhibits, ubiquitylation, ubiquitin, Tocris Bioscience, Ubiquitin-activating Enzyme E1 Inhibitor products