Cat. No. 4994
Chemical Name: 1-(3-Chloro-4-fluorophenyl)-4-[(5-n
Biological ActivityUbiquitin-activating enzyme (E1) inhibitor. Blocks degradation of p53 and cyclin D3. Inhibits NF-κB activation and induces cell death associated with ER stress. Displays antitumor effects in a mouse model of leukemia.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Xu et al (2010) The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma. Blood 115 2251. PMID: 20075161.
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Keywords: PYZD 4409, supplier, PYZD4409, ubiquitin-activating, enzyme, E1, inhibitors, inhibits, ubiquitylation, ubiquitin, Tocris Bioscience, Ubiquitin-activating Enzyme E1 Inhibitor products
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