Cat. No. 4993
Chemical Name: N-[2-[[(4-Chlorophenyl)methyl]dithi
Biological ActivityUbiquitin-activating enzyme (E1) inhibitor; prevents tumour suppressor protein p27 ubiquitination in vitro. Blocks the ubiquitin-thioester formation step of the E1 activation reaction, but displays no effect on ubiquitin adenylation.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Ungermannova et al (2012) Identification and mechanistic studies of a novel ubiquitin E1 inhibitor. J.Biomol.Screen. 17 421. PMID: 22274912.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses NSC 624206 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: NSC 624206, supplier, NSC624206, tumour, suppressor, protein, p27, ubiquitination, thioesterformation, adenylation, ubiquitin-activating, enzymes, E1, inhibitors, inhibits, Tocris Bioscience, Ubiquitin-activating Enzyme E1 Inhibitor products
Find multiple products by catalog number
New Products in this Area
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.