Cat. No. 4993
Chemical Name: N-[2-[[(4-Chlorophenyl)methyl]dithi
Biological ActivityUbiquitin-activating enzyme (E1) inhibitor; prevents tumour suppressor protein p27 ubiquitination in vitro. Blocks the ubiquitin-thioester formation step of the E1 activation reaction, but displays no effect on ubiquitin adenylation.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
Ungermannova et al (2012) Identification and mechanistic studies of a novel ubiquitin E1 inhibitor. J.Biomol.Screen. 17 421. PMID: 22274912.
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Keywords: NSC 624206, supplier, NSC624206, tumour, suppressor, protein, p27, ubiquitination, thioesterformation, adenylation, ubiquitin-activating, enzymes, E1, inhibitors, inhibits, Tocris Bioscience, Ubiquitin-activating Enzyme E1 Inhibitor products