Cat. No. 4992
Chemical Name: N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,
Biological ActivityPotent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (EC50 = 0.5 nM). Shown to inhibit Wnt-dependent processes such as tailfin regeneration and posterior axis formation in zebrafish; also reduces branching morphogenesis in cultured mouse embryonic kidneys.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Wang et al (2013) The development of highly potent inhibitors for Porcupine. J.Med.Chem. 56 2700. PMID: 23477365.
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Keywords: IWP L6, supplier, IWPL6, MBOAT, membrane-bound, O-acyltransferases, inhibitors, inhibits, porcupine, porcn, Wnt, Tocris Bioscience, PORCN Inhibitor products
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