Cat. No. 4988
Chemical Name: 1,1'-(4,4'',5',6'-Tetrahydroxy[1,1':4',1''-t
Biological ActivityInhibitor of ubiquitin-specific peptidase 4 (USP4), USP5/isopeptidase T (IsoT) and UCH-L1 deubiquitinating enzyme (DUB) activity (IC50 values are 1.5, 5.9 and 22.3 μM, respectively). Shows no significant inhibition of UCH-L3, USP2, and USP8 activities. Decreases release of TNF-α (IC50 = 0.09 nM) from RBL-2H3 mast cells. Displays anti-cancer activity decreasing viability in human colonic carcinoma cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Okada et al (2013) Vialinin A is a ubiquitin-specific peptidase inhibitor. Bioorg.Med.Chem.Lett. 23 4328. PMID: 23791076.
Onose et al (2012) Inhibitory effects of vialinin A and its analog on tumor necrosis factor-α release and production from RBL-2H3 cells. Cell Immunol. 279 140. PMID: 23246504.
Norikura et al (2011) Anticancer activities of thelephantin O and vialinin A isolated from Thelephora aurantiotincta. J.Agric.Food Chem. 59 6974. PMID: 21630659.
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Keywords: Vialinin A, supplier, inhibitors, inhibits, ubquitin, ubquitination, ubiquitin-specific, peptidase, 4, USP4, USP5, isopeptidase, T, IsoT, UCH-L1, deubiquitinating, enzymes, DUB, TNF-a, TNF-alpha, TNF, anti-cancer, Tocris Bioscience, Deubiquitinating Enzyme Inhibitor products
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