K 02288

Cat. No. 4986

K 02288 C20H20N2O4 [1431985-92-0]

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Alternative Name: K 02288a

Chemical Name: 3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol

Biological Activity

Potent and selective inhibitor of type I bone morphogenic protein (BMP) receptors (IC50 values are 1.1, 1.8, 6.4, 34.4, 220, 302 and 321 nM for ALK2, ALK1, ALK6, ALK3, ActRIIA, ALK4 and ALK5 respectively). Reduces BMP4-induced Smad1/5/8 phosphorylation in vitro (IC50 = 100 nM) and induces dorsalization of zebrafish embryos.

Technical Data

M.Wt:
352.38
Formula:
C20H20N2O4
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
1431985-92-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Mohedas et al (2013) Development of an ALK2-biased BMP type I receptor kinase inhibitor. ACS Chem.Biol. 8 1291. PMID: 23547776.

Sanvitale et al (2013) A new class of small molecule inhibitor of BMP signaling. PLoS ONE 8 62721. PMID: 23646137.

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View Related Products by Product Action

Keywords: K 02288, supplier, potent, selective, bone, morphogenic, protein, BMP, ALK2, inhibitors, inhibits, K02288, K02288a, K, 02288a, Tocris Bioscience, BMP and Other Activin Receptor Inhibitor products

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