CK 869

Cat. No. 4984

CK 869 C17H16BrNO3S [388592-44-7]

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Alternative Name: CK-0157869

Chemical Name: 2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone

Biological Activity

Inhibitor of human and bovine actin-related protein 2/3 (Arp2/3) complex. Inhibits actin polymerization (IC50= 11 μM). Does not inhibit budding or fission yeast Arp2/3 complexes.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Hetrick et al (2013) Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol. 20 701. PMID: 23623350.

Nolen et al (2009) Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature 460 1031. PMID: 19648907.

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Keywords: CK 869, supplier, CK869, CK-0157869, actin-related, protein, Arp2/3, Arp23, complex, actin, polymerization, inhibitors, inhibits, Tocris Bioscience, Actin Inhibitor products

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