Cat. No. 4983
Chemical Name: (aR,1S)-1-[(3,4-Dimethoxyphenyl)met
Biological ActivityPotent and selective orexin OX1 receptor antagonist (Kb values are 41 and 560 nM for OX1 and OX2 receptors respectively). Elicits anxiolytic effects in vivo. Brain penetrant and orally available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Steiner et al (2013) Discovery and characterization of ACT-335827, an orally available, brain penetrant orexin receptor type 1 selective antagonist. ChemMedChem 8 898. PMID: 23589487.
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Keywords: ACT 335827, supplier, ACT335827, potent, selective, OX1, antagonists, orexin-1, orexin1, orally, available, brain, penetrant, receptors, Tocris Bioscience, OX1 Receptor Antagonist products
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