Cat. No. 4982
Chemical Name: [2-Fluoro-4-[2-(4-methoxyphenyl)eth
Biological ActivitySelective negative allosteric modulator of mGlu3 (IC50 = 593 nM). Displays no activity at mGlu1, mGlu2 or mGlu4-8 at concentrations up to 30 μM. Brain penetrant.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Wenthur et al (2013) Discovery of (R)-(2-fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-hydroxypiperidin-1-yl)methanone (ML337), an mGlu3 selective and CNS penetrant negative allosteric modulator (NAM). J.Med.Chem. 56 5208. PMID: 23718281.
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Keywords: ML 337, supplier, ML337, mglu, metabotropic, glutamate, mGlu3, receptors, negative, allosteric, modulators, NAMs, selective, Tocris Bioscience, Glutamate (Metabotropic) Group II Receptor Modulator products