A 68930 hydrochloride
Cat. No. 1534
Chemical Name: cis-(±)-1-(Aminomethyl)-3,4-dihydro-
Biological ActivityPotent and selective D1-like dopamine receptor agonist (EC50 values are 2.1 and 3910 nM for D1-like and D2-like receptors respectively). Centrally active following systemic administration in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Deveney and Waddingto (1997) Psychopharmacological distinction between novel full-efficacy "D1-like" dopamine receptor agonists. Pharmacol.Biochem.Behav. 58 551. PMID: 9300618.
Kebabian et al (1990) A68930: a potent and specific agonist for the D-1 dopamine receptor. Am.J.Hypertens. 3 40S. PMID: 2143387.
Quaglia et al (1990) (1R,3S)-1-(Aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist. J.Med.Chem. 33 2948. PMID: 1977907.
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Citations are publications that use Tocris products. Selected citations for A 68930 hydrochloride include:
Mizuta et al (2013) The dopamine D1 receptor is expressed and facilitates relaxation in airway smooth muscle. PLoS One 14 89. PMID: 24004608.
Blasic et al (2012) Phosphorylation of mouse melanopsin by protein kinase A. Sci Rep 7 e45387. PMID: 23049792.
Guha et al (2012) Stimulation of the D5 dopamine receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris. J Neurochem 122 823. PMID: 22639870.
Do you know of a great paper that uses A 68930 hydrochloride from Tocris? If so please let us know.
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