A 68930 hydrochloride

Cat. No. 1534

A 68930 hydrochloride C16H17NO3.HCl [130465-39-3]

Price and Availability

For A 68930 hydrochloride pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: cis-(±)-1-(Aminomethyl)-3,4-dihydro-3-phenyl-1H-2-benzopyran-5,6-diol hydrochloride

Biological Activity

Potent and selective D1-like dopamine receptor agonist (EC50 values are 2.1 and 3910 nM for D1-like and D2-like receptors respectively). Centrally active following systemic administration in vivo.

Technical Data

Soluble to 50 mM in water
>98 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
Select another batch:

References are publications that support the products' biological activity.

Deveney and Waddingto (1997) Psychopharmacological distinction between novel full-efficacy "D1-like" dopamine receptor agonists. Pharmacol.Biochem.Behav. 58 551. PMID: 9300618.

Kebabian et al (1990) A68930: a potent and specific agonist for the D-1 dopamine receptor. Am.J.Hypertens. 3 40S. PMID: 2143387.

Quaglia et al (1990) (1R,3S)-1-(Aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist. J.Med.Chem. 33 2948. PMID: 1977907.

If you know of a relevant reference for A 68930 hydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for A 68930 hydrochloride include:

Mizuta et al (2013) The dopamine D1 receptor is expressed and facilitates relaxation in airway smooth muscle. PLoS One 14 89. PMID: 24004608.

Blasic et al (2012) Phosphorylation of mouse melanopsin by protein kinase A. Sci Rep 7 e45387. PMID: 23049792.

Guha et al (2012) Stimulation of the D5 dopamine receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris. J Neurochem 122 823. PMID: 22639870.

Do you know of a great paper that uses A 68930 hydrochloride from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: A 68930 hydrochloride, supplier, Potent, selective, D1-like, agonists, Dopamine, D1, Receptors, D5, dopaminergic, A68930, hydrochloride, Tocris Bioscience, D1 and D5 Receptor Agonist products

Quick Order

Find multiple products by catalog number

divider line

Neurodegeneration Research Product Guide

Neurodegeneration Product Guide

Our Neurodegeneration guide highlights over 275 products for neurodegeneration research. Request copy or view PDF today.

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs. Request copy or view PDF today.

divider line

Dopamine Scientific Review

Written by P. Strange & K.Neve

Dopamine Receptors Scientific Review

Our Dopamine receptors review gives an overview of the dopamine receptor subtypes, and the receptor agonists and antagonists used to study them. Request copy or view PDF today.

divider line

Cardiovascular Life Science Poster

Written by J.J. Maguire and A.P. Davenport

Cardiovascular Life Science Poster

Our Cardiovascular poster highlights the key G protein-coupled receptors involved in the regulation of vascular reactivity. Request copy or view PDF today.

divider line

Depression Life Science Poster

Written by P. Skolnich et al

Depression Life Science Poster

Our Depression poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder. Request copy or view PDF today.

divider line

Parkinson's Life Science Poster

Written by Anthony H.V. Schapira

Parkinson's Life Science Poster

Our Parkinson's disease (PD) poster summarizes the neurobiology of the disease, and highlights current therapeutic treatments for symptomatic PD. Request copy or view PDF today.

divider line

Addiction Life Science Poster

Addiction Life Science Poster

Written by Prof David Nutt, this poster summarizes the brain circuits and neurotransmitter systems that are affected by the main classes of addictive drugs. Request copy or view PDF today.

divider line

New Products in this Area

MLS 1547

G protein-biased D2 receptor partial agonist

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.