Cystamine dihydrochloride

Cat. No. 4981

Cystamine dihydrochloride C4H12N2S2.2HCl [56-17-7]

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Chemical Name: 2,2'-Diaminodiethyl disulfide dihydrochloride

Biological Activity

Transglutaminase inhibitor. Attenuates cell death induced by 3-nitropropionic acid (Cat. No. 4849) in Huntington's disease (HD) striatal cells. Also decreases aggregated and cross-linked huntingtin in transfected cells, and increases brain levels of BDNF. Shown to extend survival and improve motor performance in transgenic HD mice. Neuroprotective.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Borrell-Pages et al (2006) Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase. J.Clin.Invest. 116 1410. PMID: 16604191.

Mao et al (2006) Cystamine and cysteamine prevent 3-NP-induced mitochondrial depolarization of Huntington's disease knock-in striatal cells. Eur.J.Neurosci. 23 1701. PMID: 16623826.

Dedeoglu et al (2002) Therapeutic effects of cystamine in a murine model of Huntington's disease. J.Neurosci. 22 8942. PMID: 12388601.

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Keywords: Cystamine dihydrochloride, supplier, transglutaminase, TG, inhibitors, inhibits, neuroprotective, Huntingtons, Huntington's, disease, Tocris Bioscience, Other Transferase Inhibitor products

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