Cat. No. 4981
Chemical Name: 2,2'-Diaminodiethyl disulfide dihydrochloride
Biological ActivityTransglutaminase inhibitor. Attenuates cell death induced by 3-nitropropionic acid (Cat. No. 4849) in Huntington's disease (HD) striatal cells. Also decreases aggregated and cross-linked huntingtin in transfected cells, and increases brain levels of BDNF. Shown to extend survival and improve motor performance in transgenic HD mice. Neuroprotective.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Borrell-Pages et al (2006) Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase. J.Clin.Invest. 116 1410. PMID: 16604191.
Mao et al (2006) Cystamine and cysteamine prevent 3-NP-induced mitochondrial depolarization of Huntington's disease knock-in striatal cells. Eur.J.Neurosci. 23 1701. PMID: 16623826.
Dedeoglu et al (2002) Therapeutic effects of cystamine in a murine model of Huntington's disease. J.Neurosci. 22 8942. PMID: 12388601.
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Keywords: Cystamine dihydrochloride, supplier, transglutaminase, TG, inhibitors, inhibits, neuroprotective, Huntingtons, Huntington's, disease, Tocris Bioscience, Other Transferase Inhibitor products
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