Cat. No. 4981
Chemical Name: 2,2'-Diaminodiethyl disulfide dihydrochloride
Biological ActivityTransglutaminase inhibitor. Attenuates cell death induced by 3-nitropropionic acid (Cat. No. 4849) in Huntington's disease (HD) striatal cells. Also decreases aggregated and cross-linked huntingtin in transfected cells, and increases brain levels of BDNF. Shown to extend survival and improve motor performance in transgenic HD mice. Neuroprotective.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Borrell-Pages et al (2006) Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase. J.Clin.Invest. 116 1410. PMID: 16604191.
Mao et al (2006) Cystamine and cysteamine prevent 3-NP-induced mitochondrial depolarization of Huntington's disease knock-in striatal cells. Eur.J.Neurosci. 23 1701. PMID: 16623826.
Dedeoglu et al (2002) Therapeutic effects of cystamine in a murine model of Huntington's disease. J.Neurosci. 22 8942. PMID: 12388601.
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Keywords: Cystamine dihydrochloride, supplier, transglutaminase, TG, inhibitors, inhibits, neuroprotective, Huntingtons, Huntington's, disease, Tocris Bioscience, Other Transferase Inhibitor products
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