Cat. No. 4979
Chemical Name: 2-Methylpropanedioic acid
Biological ActivityIntracellularly produces malonate, a reversible succinate dehydrogenase inhibitor used to generate Huntington's disease models. Induces apoptotic cell death in striatal neurons.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Ehrlich (2012) Huntington's disease and the striatal medium spiny neuron: cell-autonomous and non-cell-autonomous mechanisms of disease. Neurotherapeutics 9 270. PMID: 22441874.
Beal and Ferrante (2004) Experimental therapeutics in transgenic mouse models of Huntington's disease. Nat.Rev.Neurosci. 5 373. PMID: 15100720.
McLaughlin et al (1998) Methylmalonate toxicity in primary neuronal cultures. Neuroscience 86 279. PMID: 9692761.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Methylmalonate from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Methylmalonate, supplier, methylmalonate, succinate, dehydrogenase, inhibitors, inhibits, malonate, Huntingtons, disease, HD, mitochondrial, toxins, Tocris Bioscience, Other Dehydrogenase Inhibitor products
Find multiple products by catalog number
New Products in this Area
ALDH1A1 inhibitorTC-E 5008
Selective mutant isocitrate dehydrogenase 1 (mIDH1) inhibitor; phenotypically lethalSPL 334
S-Nitrosoglutathione reductase inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.