Methylmalonate

Cat. No. 4979

Methylmalonate C4H6O4 [516-05-2]

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Chemical Name: 2-Methylpropanedioic acid

Biological Activity

Intracellularly produces malonate, a reversible succinate dehydrogenase inhibitor used to generate Huntington's disease models. Induces apoptotic cell death in striatal neurons.

Technical Data

M.Wt:
118.09
Formula:
C4H6O4
Solubility:
Soluble to 100 mM in 1.1eq. NaOH and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
516-05-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Ehrlich (2012) Huntington's disease and the striatal medium spiny neuron: cell-autonomous and non-cell-autonomous mechanisms of disease. Neurotherapeutics 9 270. PMID: 22441874.

Beal and Ferrante (2004) Experimental therapeutics in transgenic mouse models of Huntington's disease. Nat.Rev.Neurosci. 5 373. PMID: 15100720.

McLaughlin et al (1998) Methylmalonate toxicity in primary neuronal cultures. Neuroscience 86 279. PMID: 9692761.

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Keywords: Methylmalonate, supplier, methylmalonate, succinate, dehydrogenase, inhibitors, inhibits, malonate, Huntingtons, disease, HD, mitochondrial, toxins, Tocris Bioscience, Other Dehydrogenase Inhibitor products

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