Cat. No. 4978
Chemical Name: N-(Cyclopropylmethyl)-4-[[4-(3,4-di
Biological ActivityEnhances survival of human embryonic stem cells (hESCs) following enzymatic dissociation. Thought to enhance cell-ECM adhesion and activate integrin signaling. Increases adhesion of hESCs to matrigel- and laminin-coated plates, but not to gelatin-coated plates. Also podocyte-protective agent and prevents LPS-induced proteinuria in mice.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Lee et al (2015) A Podocyte-Based Automated Screening Assay Identifies Protective Small Molecules. J.Am.Soc.Nephrol 26 2741. PMID: 25858967.
Xu et al (2010) Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc.Natl.Acad.Sci.USA 107 8129. PMID: 20406903.
If you know of a relevant reference for Pyrintegrin please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Pyrintegrin from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Pyrintegrin, supplier, human, embryonic, stem, cells, hESCs, survival, culture, podocytes, renal, kidney, protective, Tocris Bioscience, Stem Cell Proliferation products
Find multiple products by catalog number
New Products in this Area
Oct4 activator; enhances iPSC reprogramming efficiencyNSC 23005 sodium
Potently promotes HSC expansion ; p18INK inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.